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A Novel Magnetic Hydrogel with Aligned Magnetic Colloidal Assemblies Showing Controllable Enhancement of Magnetothermal Effect in the Presence of Alternating Magnetic Field


Hydrogel is cross-linked polymeric network containing more than 90% water. Now there are growing interests in hydrogel research due to its excellent biocompatibility and advantage as carrier. Hydrogels have been extensively applied in organ reconstruction, soft tissue prosthesis, cell culturing substrate, and controlled drug release. One key property of hydrogel is that it can be easily integrated with other functional materials to play a synergistic role, which greatly extends the application in many areas. For instance, the hydrogel containing magnetic nanopartides can take other special effects besides the role of tissue prosthesis in postoperative organ reconstruction after excision of tumor. The presence of magnetic nanoparticles brings about the additional capabilities for the composites such as hyperthermal therapy, enhancing cell adhesion, and promoting differentiation of stem cells. Here, heat is an important physical factor in biology and medicine. Clinically, heat has been proven to be able to eradicate cancer cells, alleviate inflammation, and ease pain. The introducing of heat makes the hydrogel more biocompatible, comfortable, and safe, which are obviously requisite for tissue reconstruction after surgical excision. Furthermore, if the hydrogel is loaded with drugs, the thermo-controlled release of drugs can be realized. Thus the magnetic hydrogel is more popular clinically than the common hydrogel while serving as the prosthetic material. However, the heating modes of these purposes are different. One may require high temperature, while the other may require a moderate temperature. Therefore, how to control the heating mode of magnetic hydrogel in vivo after implantation is an imperative and challenging issue. This issue is critical for the real application of this novel material. There have been some reports on the magnetic hydrogels fabricated by versatile methods. However, the focuses were mainly refined in the issue how to get a homogeneous distribution of magnetic nanomaterials throughout the hydrogel matrices. For example, the synthesis of magnetic nanopartides in situ within hydrogel matrices has been proposed to obtain a homogeneously hybridized material. However, in these previous reports, the magnetic nanopartides were all randomly distributed inside the hydrogel without order. Additionally, the major efforts were made to the characterization of magnetic and mechanical property, seldom ranging over the control of magnetothermal performance. However, the control of magnetothermal performance is actually a very important issue clinically. For the homogeneous magnetic hydrogels, the magnetothermal behavior can only be modulated by the frequency of alternating magnetic field after the hydrogel materials are implanted into body. This is because the magnetothermal effect of magnetic nanopartides actually just costs a very little energy of the alternating magnetic field. Thus, the machine to generate the alternating magnetic field is similar to no-load running. In this case, the output intensity of field is hard to adjust by altering the current so that the magnetothermal behavior of nanoparticles can only be controlled by the frequency of alternating magnetic field. Unfortunately, the frequency is very hard to change in real time. Therefore, the heating temperature of magnetic nanopartides is difficult to alter arbitrarily so that the multifunctions of heat are unable to be realized in the practical application.......

【作者名称】: Ke Hu, Jianfei Sun, Zhaobin Guo, Peng Wang, Qiang Chen, Ming Ma
【作者单位】: Department of Biological Science and Medical Engineering Jiangsu Laboratory for Biomaterials and Devices State Key Laboratory of BioElectronics Southeast University Nanjing 210096, China, Department of Biological Science and Medical Engineering Jiangsu Laboratory for Biomaterials and Devices State Key Laboratory of BioElectronics Southeast University Nanjing 210096, China, Department of Biological Science and Medical Engineering Jiangsu Laboratory for Biomaterials and Devices State Key Laboratory of BioElectronics Southeast University Nanjing 210096, China, Department of Biological Science and Medical Engineering Jiangsu Laboratory for Biomaterials and Devices State Key Laboratory of BioElectronics Southeast University Nanjing 210096, China, Department of Biological Science and Medical Engineering Jiangsu Laboratory for Biomaterials and Devices State Key Laboratory of BioElectronics Southeast University Nanjing 210096, China, Department of Biological Science and Medical Engineering Jiangsu
【关 键 词】: A Novel Magnetic Hydrogel with Aligned Magnetic Colloidal Assemblies Showing Controllable Enhancement of Magnetothermal Effect in the Presence of Alternating Magnetic Field
【期刊名称】: Advanced Materials
【期刊论文数据库】: [DBS_Articles_01]
【期刊论文编号】: 109,691,274
【摘要长度】: 3,494
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