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Correlation between Three Pregnancy Characteristics (Age, Parity, βhCG Level) and pAkt Immunoexpression on Complete Hydatidiform Mole


The incidence ofhydatidiform mole as pregnancy failure is still high in Asia, leading to highmortality and morbidity. Several risk factors play roles in the occurrence ofhydatidiform mole, including age and parity. Until now, ,-human chronic gonadotropin (,hCG)is used to predict the risk and development of hydatidiform mole. Akt, alsoknown as protein kinase B (PKB), is a downstream effector of the intracellularphosphatidyl,inositol 3-kinase (PI3K) signaling pathway, which is a centralregulatory pathway for cell proliferation, growth, differentiation, andsurvival. This study aimed to analyze the correlation between three pregnancycharacteristics ,. age, parity,levels of ,hCG and pAktimmunoexpression. Cross sectional study was conducted on 30 samples of completehydatidiform mole (CHM). The ,hCGcontent was measured by ELISA method. The immunoexpression of pAkt was measuredby immunohistochemical staining using the phospho-Akt antibody (Ser473)(736E11) Rabbit mAb # 3787 (CST). Cells with po......

【作者名称】: Zulvayanti Z. Hidayat, Sofie R. Krisnadi, Achadiyani Wiyono
【关 键 词】: Complete Hydatidiform Mole, Akt, βhCG, Age, Parity, Open Access Library
【网站名称】: OALIB数据库
【期刊论文数据库】: [DBS_Articles_01]
【期刊论文编号】: 103,633,809
【摘要长度】: 1,000
【栏目名称】: 所有文件
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