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NANOGELS AND NANOCOMPOSITES FOR OVERDOSED DRUG AND POLLUTANT EXTRACTION


Controlled polymerization in inverse microemulsion system and polymer adsorption have been used to design and generate special nanogels and nanocomposites. The size and the conformation of the resultant polymeric nanogels, the conformation and/or association of the adsorbed species of the nanocomposites can be controlled and the resultant nanoparticles have considerable potential for the removal of overdose drugs and pollutants. Polyacrylamide nanogels of nanosized crosslinked particles were synthesized in our work by inverse microemulsion polymerization. The prepared nanogels had very narrow size distributions and can form stable suspension in water. By systematic modification, a series of functional nanogels, i.e. (a) hydrophobic nanogels, (b) ionic nanogels and (c) nanogels with both hydrophobic and ionic groups, were made and drug extraction experiments carried out with them. The chemically modified nanogels showed marked ability for drug extraction when compared to that of unmodified nanogels. The extraction efficiencies of hydrophobic, ionic and dually modified nanogels were 80%, 78% and 89% as opposed to 15% for unmodified nanogels. By characterizing the effects of these functional groups on the drug loading properties of nanogels, methods for controlling the range and capacity of the response of nanogels can be designed. Similarly, nanocomposite particles were prepared through controlled polymer adsorption for nanoparticle coating. Using this process, it was possible to make nanocomposites of alumina, silicon nitride, titania and hematite with desired local composition and microstructure. The former two were used as core particles and later two were used as shell particles. The attachment of the shell particles to core particles was achieved using controlled polymer adsorption. Removal of excess polymer was accomplished without detaching the pre-adsorbed polymers by a specific stepwise washing scheme. This controlled removal is an absolute process requirement in order to prevent undesirable self-flocculation of nanoparticles. By removing the core particles, by evaporation or leaching, foamy composites with capability tooo extract/store actives can be prepared. This scheme provides a new process for the preparation of novel nanocomposite mateerials.......

【作者名称】: P. Somasundaran, Fang Liu, T. Chen, Carl C. Gryte
【作者单位】: Columbia University 911 Mudd Building 500 W 120th Street New York, NY 1002
【关 键 词】: NANOGELS AND NANOCOMPOSITES FOR OVERDOSED DRUG AND POLLUTANT EXTRACTION
【会议名称】: Conference on Nanoparticles 2002 Oct 28-29, 2002 New York, NY, U.S.A.
【期刊论文数据库】: [DBS_Articles_01]
【期刊论文编号】: 100,835,274
【摘要长度】: 2,296
【会议地点】: New York, NY(US)
【会议组织】: Columbia University 911 Mudd Building 500 W 120th Street New York, NY 1002
【会议时间】: 2002
【上篇论文】: 外文会议 - Hard x-ray spectral energy distributions from pulsed power generators measured by transmission crystal spectrometers
【下篇论文】: 外文会议 - Photothermal and immunological reactions against metastatic tumors using laser photosensitizer immunoadjuvant

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